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Efficient Synthesis of a New Structural Phenanthro[9,10,3‘,4‘]indolizidine Starting from Pyrrole

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A new structural phenanthroindolizidine, 2,3,6,7-tetramethoxyphenanthro[9,10,3‘,4‘]indolizidine, has been synthesized efficiently from pyrrole. An important feature of this synthesis is that intramolecular oxidative coupling and rearrangement of 6,7-bis(3,4-dimethoxyphenyl)-8-methoxy-1,2,3-trihydroindolizin-5-one by using VOF3 and TFA have been achieved in one pot.

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2016-06-03
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