Summary of direction and strength of β relative to EA.

ap values were computed from the binomial sign test against null expectation of 50% in same direction, not adjusted for multiple tests.bMaximum number of samples per population. Not all SNPs were genotyped in all PAGE substudies; detailed numbers genotyped per variant are available in Table S2.cAlthough some effects were observed where the sign of the coefficient differed between EA and AA, in none of these cases were both coefficients significantly different from zero, so no significantly opposite effects were observed in any non-EA population.dStrength was evaluated only for index SNPs that replicated in EA, and showed differential effects in the non-EA population (ßpop≠ßEA). p values computed from the binomial sign test against null expectation of 50% stronger, not adjusted for multiple tests.*p**p***p