KRas G12C in complex with Compound 7b
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KRas G12C in complex with Compound 7b Descriptor: 1-[7-[6-chloranyl-2-(1-ethylpiperidin-4-yl)oxy-8-fluoranyl-7-(5-methyl-1~{H}-indazol-4-yl)quinazolin-4-yl]-2,7-diazaspiro[3.5]nonan-2-yl]propan-1-one, GUANOSINE-5'-DIPHOSPHATE, Isoform 2B of GTPase KRas, ... Authors: Amano, Y. Deposit date: 2022-07-01 Release date: 2022-08-10 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Discovery and biological evaluation of 1-{2,7-diazaspiro[3.5]nonan-2-yl}prop-2-en-1-one derivatives as covalent inhibitors of KRAS G12C with favorable metabolic stability and anti-tumor activity. Bioorg.Med.Chem., 71, 2022
创建时间：
2022-07-01
