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资源简介：
Gene therapy of Mpl -/- mouse LSK cells
应用场景：
创建时间：
2011-01-03
相关数据集
Transient Inhibition of 53BP1 Increases the Frequency of Targeted Integration in Human Hematopoietic Stem and Progenitor Cells
Genome editing by homology directed repair (HDR) is leveraged to precisely modify the genome of therapeutically relevant hematopoietic stem and progenitor cells (HSPCs). Here, we present a new approac
NIAID Data Ecosystem50
High-throughput characterization of hematopoietic stem cell engraftment after intravenous and intracerebroventricular dosing
Hematopoietic stem/progenitor cell gene therapy (HSPC-GT) has shown clear neurological benefit in rare diseases, which is achieved through the engraftment of genetically modified microglia-like cells
NIAID Data Ecosystem20
Expansion, in vivo-ex vivo cycling and genetic manipulation of primary human hepatocytes
Primary human hepatocytes (PHH) are an essential tool for modeling drug metabolism and liver disease. However, variable plating efficiencies, short lifespan in culture and resistance to genetic manipu
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Foamy virus vector insertion junctions within murine-engrafted human LAD-1 HSPCs
To evaluate foamy virus vector insertion junctions within murine-engrafted human LAD-1 blood stem cells.
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Expression of human alpha-globin and mouse/human hybrid beta-globin genes in murine hemopoietic stem cells transduced by recombinant retroviruses.
Murine cell lines releasing helper-free recombinant retroviruses containing human alpha-globin and mouse/human hybrid beta-globin genes were generated. The expression of the hybrid beta-globin gene bu
PubMed Central20
