Single-Cell Map of Diverse Immune Phenotypes in Liver Microenvironment

As hepatocellular carcinoma (HCC) is the most common type of liver cancer, ranks the sixth leading cause of cancer-related death worldwide (Bray, F., et al. 2018, CA Cancer J Clin 68: 394-424), it is imminent to uncover the regulatory mechanism of immune cells in the liver microenvironment. Here, we perform deep single-cell RNA sequencing on immune cells isolated from tumors of hepatocellular carcinoma patients and healthy liver from donors. Liver perfusates from HCC patients and healthy donors.