Single-cell RNA Sequencing reveals the expansion of Cytotoxic CD4+ T lymphocytes and the heterogeneity of pathogenesis in primary Sjögren's syndrome patients

By single cell RNA sequencing,our data revealed disease-specific immune cell subsets and provide some potential new targets of pSS, specific expansion of CD4+ CTLs may be involved in the pathogenesis of pSS, which might give a valuable insights for therapeutic interventions of pSS. Overall design: We applied single cell RNA sequencing (scRNA-seq) to 57, 288 peripheral blood mononuclear cells (PBMCs) from 5 patients with pSS and 5 healthy controls. The immune cell subsets and susceptibility genes involved in the pathogenesis of pSS were analyzed.