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CRISPR activation screen identifies BCL-2 proteins and B3GNT2 as drivers of cancer resistance to T cell-mediated cytotoxicity

NIAID Data Ecosystem2026-03-13 收录

癌症免疫治疗耐药性

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数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE159540 数据链接链接失效反馈

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This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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创建时间：

2022-04-27

衰老生物学寿命实验

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The advent of feeding based RNAi in Caenorhabditis elegans led to an era of gene discovery in aging research. Hundreds of gerogenes were discovered, and many are evolutionarily conserved, raising the

NIAID Data Ecosystem80

CROP-Seq in Primary Human T Cells

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T细胞激活转录组

We adapted sgRNA lentiviral infection and Cas9 electroporation (SLICE) to allow for CROP-Seq (Datlinger et al, Nat Med 2017) in primary cells. We used a library of 48 sgRNA, derived from GW screens, t

NIAID Data Ecosystem60

BarSeq of Tailocin Antagonism Pseudomonas Mutant Fitness Assays

微生物遗传相互作用

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Here we apply tailocins to barcoded random transposon-insertion (RB-TnSeq) mutant libraries of 4 groundwater Pseudomonads (FW300-N2C3, FW300-N2E2, FW300-N2E3, GW456-L13) to identify genetic determinan

NIAID Data Ecosystem40

Cancer Cell Resistance to IFN? Can Occur via Enhanced Double-Strand Break Repair Pathway Activity [CRISPR screen]

癌症免疫治疗耐药性

DNA双链断裂修复

The pleiotropic cytokine interferon-gamma (IFN?) is known to be associated with cytostatic, anti-proliferation, and pro-apoptosis functions in cancer cells. However, cancer cells can become resistant

NIAID Data Ecosystem70

Data sheet index below 1.

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肿瘤代谢

In vitro and in vivo growth screen data, HCC827 cells, Source data for Fig 1. Mini-library CRISPRi screen in HCC827 cells, raw data. The read counts for each sgRNA in all in vitro and in vivo (flank a

Figshare2022-09-22 更新50

CRISPR activation screen identifies BCL-2 proteins and B3GNT2 as drivers of cancer resistance to T cell-mediated cytotoxicity

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