Supporting information for Linkage disequilibrium-based quality control for large-scale genetic studies. Appendix for methods; comparisons of different priors and error models; list of SNPs and correc
Specialized surveillance mechanisms are essential to maintain the genetic integrity of germ cells, which are not only the source of all somatic cells but also of the germ cells of the next generation.
Next-generation sequencing technology (NGS) enables the discovery of nearly all genetic variants present in a genome. A subset of these variants, however, may have poor sequencing quality due to limit