Endosomal sorting regulates PD-L1 trafficking and enhances immunotherapy efficacy

Name: Endosomal sorting regulates PD-L1 trafficking and enhances immunotherapy efficacy
Creator: School of Pharmaceutical Sciences, Shandong University
Published: 2025-03-15T21:00:43+08:00

integrated proteome resources2026-02-07 收录

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蛋白质运输

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资源简介：

Endosomal sorting regulates PD-L1 trafficking and enhances immunotherapy efficacy

提供机构：

School of Pharmaceutical Sciences, Shandong University

创建时间：

2025-03-15

NK细胞体外规模化扩增的数据集

NK细胞扩增

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一、单个核细胞的制备：健康供者/患者外周血、脐带血、胎盘血，经密度梯度离心法获取单个核细胞。二、细胞大量扩增：使用无血清培养基，在37°C、5% CO₂恒温培养条件下，维持最佳细胞密度（通常1-2×10⁶ cells/mL）。每天换液，补充新鲜细胞因子进行规模化扩增，培养14天后进行数量与活力、纯度、表型验证。三、数据处理与分析：流式细胞术鉴定NK细胞表面标志（CD3-CD56+），通过Flo

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Ipilimumab-induced side effects of the endrocrine system.

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内分泌系统

*case is detailed in the result section. alisted treatments are systemic treatments unless otherwise specified. btumor-free high-risk stage III melanoma (AJCC 2009); adjuvant administration of ipilimu

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Comprehensive analysis of adverse events associated with T-cell engagers using the FAERS database

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T-cell engagers (TCEs) are transformative immunotherapies with significant potential in treating hematologic malignancies and solid tumors. However, their real-world safety profiles remain inadequatel

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Dynamic single-cell RNA sequencing identifies immunotherapy persister cells following PD-1 blockade. Dynamic single-cell RNA sequencing identifies immunotherapy persister cells following PD-1 blockade

单细胞RNA测序

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We report results of transcriptional profiling of ex vivo MC38 murine organotypic tumor spheroids following programmed death-1 (PD-1) blockade compared to isotype control IgG treatment by bulk and sin

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Additional file 5 of Blinatumomab-induced T cell activation at single cell transcriptome resolution

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单细胞转录组学

Additional file 5: Table S4. Signature genes in each T cell subcluster in patient derived model.

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