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Homo sapiens Targeted loci (BRCA1). Homo sapiens

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BRCA1基因功能验证

CRISPR碱基编辑

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA529534 数据链接链接失效反馈

官方服务：

资源简介：

Functional analysis of BRCA1 missense variants via time-course mutation analysis of CRISPR-based base editing

应用场景：

创建时间：

2019-03-27

人类基因组编辑

CRISPR碱基编辑

Recently, base editors, composed of cytidine deaminase, Cas9 nickase (nCas9), and uracil DNA glycosylase inhibitor (UGI), have recently been developed to substitute a C at a target site with T without

NIAID Data Ecosystem70

Table_1_Highly Efficient CRISPR-Mediated Base Editing in Sinorhizobium meliloti.DOCX

CRISPR碱基编辑

根瘤菌基因组操作

Rhizobia are widespread gram-negative soil bacteria and indispensable symbiotic partners of leguminous plants that facilitate the most highly efficient biological nitrogen fixation in nature. Although

NIAID Data Ecosystem30

Multiplexed inactivation of endogenous genes by base-editor-mediated multi-stop system

CRISPR碱基编辑

基因编辑脱靶效应

One of the major hurdles in CRISPR application is the present of unwanted off-target mutations. To achieve multiple gene targeting with minimal off-target side-effects, we evaluated the fidelity of hA

NIAID Data Ecosystem30

Highly efficient CRISPR-mediated base editing for the gut Bacteroides spp. with pnCasBS-CBE

肠道菌群基因编辑

CRISPR碱基编辑

We constructed a pnCasBS-CBE system for base editing in the Bacteroides thetaiotaomicron to expand their genetic toolkit, which can efficiently convert a C:G to a T:A in the genome. As a functional pr

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Single CRISPR base editors to induce simultaneous C-to-T and A-to-G mutations

CRISPR碱基编辑

高通量测序

High-throughput sequencing data of CRISPR base editing assays in human cells

NIAID Data Ecosystem30