Additional file 3 of Transcriptomics and miRNomics data integration in lymphoblastoid cells highlights the key role of immune-related functions in lithium treatment response in Bipolar disorder

Additional file 3 Supplementary Table 3. List of 54 statistically significant pathways modulated by 335 differentially expressed genes identified using IPA. Ratio is calculated as the number of analysis-ready genes in a given pathway, divided by the total number of genes in the reference dataset that makes up that pathway. Z-score predicts the activation state of the canonical pathways, using the gene expression patterns of the genes within the pathway. A negative z value connotes an overall pathway’s inhibition while a positive z value is representative of an overall pathway’s activation. A NaN z-score is assigned to a pathway when gene expression patterns within that pathway are not sufficient to perform the analysis and predict the activation/inhibition state.