Qualitative analyses of NOE-mediated CEST contrast on 3D co-registered data.

Peritumoral hyperintensity: Comparison of the extent of the peritumoral hyperintensity on CEST and T2-weighted images (smaller* = total extent smaller on CEST contrast but exceeding the margins of the T2 edema in one direction). Appearance of isolated high intensity regions (HIR) on MTRasym: Evaluation if isolated CEST HIR on MTRasym displayed in the area of CE-T1 tumor or T2 peritumoral edema (Y = Yes, N = No). Satellite lesions: Fraction of contrast enhanced satellite lesions identified on CE-T1 images that were also clearly hyperintense on CEST (∅ = no satellite lesion detected).