Data from: Comparison of cerebral blood volume and plasma volume in untreated intracranial tumors

Purpose: Plasma volume and blood volume are imaging-derived parameters that are often used to evaluation intracranial tumors. Physiologically, these parameters are directly related, but their two different methods of measurements, T1-dynamic contrast enhanced (DCE)- and T2-dynamic susceptibility contrast (DSC)-MR utilize different model assumptions and approaches. This poses the question of whether the interchangeable use of T1-DCE-MRI derived fractionated plasma volume (vp) and relative cerebral blood volume (rCBV) assessed using DSC-MRI, particularly in glioblastoma, is reliable, and if this relationship can be generalized to other types of brain tumors. Our goal was to examine the hypothetical correlation between these parameters in three most common intracranial tumor types. Methods: Twenty-four newly diagnosed, treatment naïve brain tumor patients, who had undergone DCE- and DSC-MRI, were classified in three histologically proven groups: glioblastoma (n=7), meningioma (n=9), and intraparenchymal metastases (n=8). The rCBV was obtained from DSC after normalization with the normal-appearing anatomically symmetrical contralateral white matter. Correlations between these parameters were evaluated using Pearson (r), Spearman's (ρ) and Kendall’s tau-b (τB) rank correlation coefficient. Results: The Pearson, Spearman and Kendall’s correlation between vp with rCBV were r=0.193, ρ=0.253 and τB=0.33 (p-Pearson=0.326, p-Spearman=0.814 and p-Kendall=0.823) in glioblastoma, r=-0.007, ρ=0.051 and τB=0.135 (p-Pearson=0.970, p-Spearman=0.765 and p-Kendall=0.358) in meningiomas, and r= 0.289, ρ=0.228 and τB= 0.239 (p-Pearson=0.109, p-Spearman=0.210 and p-Kendall=0.095) in metastasis. Conclusion: Results indicate that no correlation exists between vp with rCBV in glioblastomas, meningiomas and intraparenchymal metastatic lesions. Consequently, these parameters, as calculated in this study, should not be used interchangeably in either research or clinical practice.研究目的：血浆容积与血容量是常用于评估颅内肿瘤的影像学衍生参数。生理学上，两类参数存在直接关联，但两种测量方法——T1动态对比增强（T1-dynamic contrast enhanced, DCE）磁共振成像与T2动态磁化率对比（T2-dynamic susceptibility contrast, DSC）磁共振成像——采用了不同的模型假设与分析策略。由此引发一个问题：在胶质母细胞瘤中，通过T1-DCE-MRI获取的分割血浆容积（fractionated plasma volume, vp）与经DSC-MRI评估的相对脑血容量（relative cerebral blood volume, rCBV），二者是否可互换使用？这种相关性能否推广至其他脑肿瘤类型？本研究旨在探讨三种最常见颅内肿瘤类型中，这两类参数间的潜在关联。 研究方法：本研究纳入24例初诊且未接受过治疗的脑肿瘤患者，所有受试者均完成了DCE-MRI与DSC-MRI扫描。经组织病理学证实，将患者分为三组：胶质母细胞瘤组（n=7）、脑膜瘤组（n=9）以及脑实质转移瘤组（n=8）。rCBV通过将DSC-MRI数据与外观正常的解剖对称对侧白质进行归一化处理后获得。采用Pearson相关系数（r）、Spearman秩相关系数（ρ）以及Kendall tau-b秩相关系数（τB）对两类参数间的相关性进行评估。 研究结果：胶质母细胞瘤组中，vp与rCBV的Pearson、Spearman及Kendall相关系数分别为r=0.193、ρ=0.253、τB=0.33（Pearson检验p值=0.326，Spearman检验p值=0.814，Kendall检验p值=0.823）；脑膜瘤组中分别为r=-0.007、ρ=0.051、τB=0.135（Pearson检验p值=0.970，Spearman检验p值=0.765，Kendall检验p值=0.358）；脑实质转移瘤组中分别为r=0.289、ρ=0.228、τB=0.239（Pearson检验p值=0.109，Spearman检验p值=0.210，Kendall检验p值=0.095）。 研究结论：结果表明，在胶质母细胞瘤、脑膜瘤及脑实质转移瘤病灶中，vp与rCBV均无显著相关性。因此，本研究中计算得到的这两类参数，无论在科研还是临床实践中，均不应互换使用。