Phenotypes examined in association analyses of the 511 KCNJ1 variants in the UK Biobank.

Phenotypes were selected from the pool of the ~200,000 participants in the UK Biobank and included three groups: (1) 25 disease phenotypes for relevance to ROMK function, Bartter syndrome type II, and hypertension [9,68] (e.g., systolic and diastolic blood pressure, serum urea, creatinine, calcium, and phosphate, and urine potassium and sodium), (2) 15 phenotypic codes, or “phecodes” [34], associated with Bartter syndrome type II, and (3) 168 continuous/quantitative metabolomics biomarkers. Each group of phenotypes was listed in one tab of the Excel file. (XLSX)