Base editors are valuable tools for genome editing, but in-depth characterization of base editors is currently limited by a lack of large-scale gRNA activity datasets. Here, we performed a genome-scal

NIAID Data Ecosystem70

Replacing the SpCas9 HNH domain by deaminases generates compact base editors with an alternative targeting scope. Replacing the SpCas9 HNH domain by deaminases generates compact base editors with an alternative targeting scope

基因编辑工具

碱基编辑器

Base editors are RNA-guided deaminases that enable site-specific nucleotide transitions. The targeting scope of these Cas-deaminase fusion proteins critically depends on the availability of a protospa

NIAID Data Ecosystem40

Plant genome editing with different CBEs systems

转基因植物基因组

碱基编辑器

Plant protoplast HTS data with different CBEs systems

NIAID Data Ecosystem70

Engineering of adenine base editor with improved editing activity across NNN PAMs. Homo sapiens

碱基编辑器

PAM序列

Engineering of adenine base editor with improved editing activity across NNN PAMs

NIAID Data Ecosystem60