Total Synthesis of Akuammiline Alkaloid (−)-Vincorine via Intramolecular Oxidative Coupling
收藏NIAID Data Ecosystem2026-03-07 收录
数据链接：
官方服务：
资源简介：
An asymmetric total synthesis of the Akuammiline alkaloid (−)-vincorine (18 steps from 5-methoxytryptamine, 5% overall yield) is described. The key steps include Pd-catalyzed direct C–H functionalization of indole derivatives, organocatalyzed asymmetric Michael addition of aldehydes to alkylidene malonates, and intramolecular oxidative coupling between indole and malonate moieties.
创建时间：
2012-06-06
