Effect of each of the four BH sonication parameters on significant increase in lesion volume and focal region temperature are summarized.

Increasing acoustic power did not result in an increase in lesion volume, whereas temperature distribution and area of lethal thermal dose increased. While increasing number of cycles/pulse, both lesion volume and temperature distribution increased. No increase in either lesion volume or temperature distribution was observed while increasing total sonication time, but area of lethal thermal dose increased. Varying pulse repetition frequency resulted in increased lesion volume and temperature distribution and area of lethal thermal dose.