Modularity of OCT4 underlies its functional diversity in reprogramming and embryonic development.
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2025-10-03
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Self-Renewing Presomitic Mesoderm Progenitor Lines Reprogrammed from human urine cells [xxx scRNA-seq]. Self-Renewing Presomitic Mesoderm Progenitor Lines Reprogrammed from human urine cells [xxx scRNA-seq]
Vertebrae formation is the defining feature of all vertebrates1,2. Yet, each vertebrate species appears to have a unique timing mechanism for forming somites along the vertebral column3-5. Human verte
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Lethal phenotype-based database screening identifies ceramide as a negative regulator of primitive streak formation. Lethal phenotype-based database screening identifies ceramide as a negative regulator of primitive streak formation
In early embryogenesis, the primitive streak (PrS) generates the mesendoderm and is essential for organogenesis. However, because the PrS is a minute and transient tissue, elucidating the mechanism of
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Direct Conversion of Trophoblast Stem Cells into Pluripotent Stem Cells by Oct4
Direct Conversion of Trophoblast Stem Cells into Pluripotent Stem Cells by Oct4
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Chromatin Accessibility Dynamics during Chemical Induction of Pluripotency [RNA-seq]. Chromatin Accessibility Dynamics during Chemical Induction of Pluripotency [RNA-seq]
Chemical induction of pluripotency (CIP) is an ideal way to reprogram cell fate, but remains poorly understood. Here we report the development of an efficient CIP protocol and the chromatin accessibil
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Overlapping roles and requirement of histone deacetylase 1 and 2 in lineage development and genome-wide DNA methylation during mouse preimplantation development
Epigenetic modifications, including DNA methylation and histone modifications, are reprogrammed considerably following fertilization during mammalian early embryonic development. Incomplete epigenetic
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