SRSF1 overexpression in pancreatic normal ductal and KC organoids

NIAID Data Ecosystem2026-03-12 收录

胰腺癌可变剪接

Kras突变剪接调控

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA747810 数据链接链接失效反馈

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资源简介：

SRSF1-mediated alternative splicing changes based on wild type or KrasG12D context.

创建时间：

2021-07-18

Genome wide screening for alternative splicing events in pancreatic cancer. Homo sapiens

胰腺癌可变剪接

肿瘤剪接变异

We used Affymetrix GeneChip® Human Exon 1.0 ST Arrays to identify alternative splicing events in 15 samples of PDAC compared to 6 non-tumor samples. Several commercial and open source software approac

NIAID Data Ecosystem20

Expression data from human pancreatic cancer cell lines and mouse orthotopic tumors generated using human PDAC cell lines replete and depleted for RBFOX2. Expression data from human pancreatic cancer cell lines and mouse orthotopic tumors generated using human PDAC cell lines replete and depleted for RBFOX2

胰腺癌可变剪接

RBFOX2基因调控

RBFOX2 is an RNA binding protein that directs alternative splicing. In this study, we characterized RBFOX2-mediated alternative splicing in pancreatic cancer (PDAC) In this dataset, we assayed gene-le

NIAID Data Ecosystem10

Gene expression and alternative splicing in pancreatic ductal adenocarcinoma (PDAC) [gene level]. Homo sapiens

胰腺癌可变剪接

胰腺基因表达

Alternative splicing is a key event to human transcriptome and proteome diversity and complexity. Recent evidence suggests that pancreatic cancer might possess particular patterns of splice variation

NIAID Data Ecosystem20

Altered mRNA splicing by mutant p53 activates oncogenic RAS in pancreatic cancer

胰腺癌可变剪接

p53突变剪接调控

Integrating transcriptomic analyses of both clinical PDAC and PDAC models, we identified that the most common neomorphic TP53 mutation (p53R175H) rewires RNA splicing promoting transcriptome-wide rete

NIAID Data Ecosystem00

SRSF1 overexpression in pancreatic normal ductal and KC organoids

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