Altered mRNA splicing by mutant p53 activates oncogenic RAS in pancreatic cancer
收藏NIAID Data Ecosystem2026-04-25 收录
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资源简介：
Integrating transcriptomic analyses of both clinical PDAC and PDAC models, we identified that the most common neomorphic TP53 mutation (p53R175H) rewires RNA splicing promoting transcriptome-wide retention of cassette exons bearing cytosine(C)-rich sequences. Overall design: Examination of splicing changes attributed to p53R175H in patient derived organoids (HT42), murine pancreatic cancer cell line (KPC), murine pancreatic intraepithelial neoplasia (PanIN).
创建时间：
2020-03-12
