β cell specific Crif1 haploinsufficiency effect.

CRIF1 is a mitochondrial protein essential for the synthesis and formation of the OxPhos complex in the inner mitochondrial membrane. Beta cell specific Crif1 haploinsufficiency resulted in defect of first phase insulin secretion, and caused islet cell composition change as well as proliferation of beta cell for a compensation to maintain metabolic homeostasis. These results suggest that mitochondrial OxPhos function of beta cell has roles for beta cell compensation as well as insulin secretion. Islet mRNA profiles of 14 weeks old Control and Crif1beta+/-CRIF1是一种线粒体蛋白，对线粒体内膜氧化磷酸化（OxPhos）复合物的合成与组装至关重要。β细胞（beta cell）特异性Crif1单倍剂量不足可引发第一时相胰岛素分泌缺陷，造成胰岛细胞组成改变，并促使β细胞增殖以代偿性维持代谢稳态。上述结果表明，β细胞的线粒体氧化磷酸化功能既参与胰岛素分泌过程，也在β细胞代偿机制中发挥作用。本数据集涵盖14周龄对照组与Crif1β+/-（Crif1beta+/-）小鼠的胰岛mRNA表达谱。