Figure S1 - Early Growth Inhibition Is Followed by Increased Metastatic Disease with Vitamin D (Calcitriol) Treatment in the TRAMP Model of Prostate Cancer

Effect of vitamin D compounds on tumor incidence in TRAMP mice. (A) Tumor incidence (%) in androgen-stimulated TRAMP mice following treatment with vehicle control (n = 40), calcitriol (n = 41), or QW (n = 42) at 18 weeks-of-age. (B) Tumor incidence (%) at 24 weeks-of-age in castrate TRAMP mice following post-castration treatment with vehicle control (n = 33), calcitriol (n = 31) or QW (n = 30). (C) Tumor incidence (%) at 24 weeks-of-age in castrate TRAMP mice following pre-castration treatment with vehicle control (n = 29) or calcitriol (n = 34). Chi-Square tests and Fisher's exact tests were performed to determine if there were any associations between treatment group and tumor incidence. (DOCX)