Crystal structure of LCK SH2 complexed with nonpeptide phosphotyrosine mimetic

Crystal structure of LCK SH2 complexed with nonpeptide phosphotyrosine mimetic Descriptor: (4-{2-ACETYLAMINO-2-[1-(3-CARBAMOYL-4-CYCLOHEXYLMETHOXY-PHENYL)-ETHYLCARBAMOYL}-ETHYL}-2-PHOSPHONO-PHENOXY)-ACETIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE LCK Authors: Kawahata, N.H, Yang, M.H, Luke, G.P, Shakespeare, W.C, Sundaramoorthi, R. Deposit date: 2001-04-27 Release date: 2002-05-01 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.2 Å) Cite: A novel phosphotyrosine mimetic 4'-carboxymethyloxy-3'-phosphonophenylalanine (Cpp): exploitation in the design of nonpeptide inhibitors of pp60(Src) SH2 domain. Bioorg.Med.Chem.Lett., 11, 2001