Somatic stem cells mediate tissue maintenance for the lifetime of an organism. Despite the well-established longevity that is a prerequisite for such function, accumulating data argue for compromised

NIAID Data Ecosystem50

Additional file 6 of The mtDNA mutation spectrum in the PolG mutator mouse reveals germline and somatic selection

线粒体DNA突变

PolG诱变模型

Additional file 6. PolG Indel Mutations Dataset. Dataset containing all PolG Indel mutations. Output from the script “PolG_bcf_to_excel”

Figshare2021-11-26 更新40

Duplex sequencing rhesus macaque mtDNA (somatic tissues and oocytes)

衰老生物学

线粒体DNA突变

Duplex sequencing of mtDNA from rhesus macaque somatic tissues (liver, skeletal muscle, and heart), and single oocytes was performed to study the effect of aging on mtDNA substitution frequencies. Mac

NIAID Data Ecosystem50

Quantitative variation in m.3243A>G mutation produce discrete changes in energy metabolism. Quantitative variation in m.3243A>G mutation produce discrete changes in energy metabolism

线粒体DNA突变

能量代谢调控

Mitochondrial DNA (mtDNA) 3243A>G tRNALeu(UUR) heteroplasmic mutation (m.3243A>G) exhibits clinically heterogeneous phenotypes. While the high mtDNA heteroplasmy exceeding a critical threshold causes

NIAID Data Ecosystem40

Comparison of patients with and without the 4977 deletion.

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