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SIRT6 regulates redox homeostasis in human mesenchymal stem cells by the transactivation of NRF2

ChEBI2016-01-04 更新2026-07-12 收录

细胞氧化还原调控

NRF2信号通路

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-64642 数据链接链接失效反馈

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资源简介：

SIRT6 regulates redox homeostasis in human mesenchymal stem cells by the transactivation of NRF2

应用场景：

创建时间：

2016-01-04

细胞衰老机制

NRF2信号通路

Nrf2-mediated fibroblast reprogramming drives cellular senescence by targeting the matrisome. ECM was isolated from WT and NRF2-/- mouse fibroblasts and analyzed by label-free quantification.

NIAID Data Ecosystem40

The catalytic mechanism of vitamin K epoxide reduction in a cellular environment

酶催化机制

细胞氧化还原调控

Vitamin K epoxide reductases (VKOR) constitute a major family of integral membrane thiol oxidoreductases. In humans, VKOR sustains blood coagulation and bone mineralization through the vitamin K cycle

NIAID Data Ecosystem40

Summary of Trx redox status following TR1 knockdown and Sec-deficient TR1 expression: Percent Trx in each redox state (% total).

TR1敲低与突变体对Trx氧化还原的影响

细胞氧化还原调控

Summary of the 6 possible redox states, from the most oxidized (state 1) to the least (state 6) of Trx in RKO cells with endogenous TR1 (si-Scramble), with endogenous TR1 knocked-down (si-TR1), or end

NIAID Data Ecosystem40

A cellular mechanism to detect and alleviate reductive stress. A cellular mechanism to detect and alleviate reductive stress

还原应激响应

细胞氧化还原调控

Metazoan organisms rely on conserved stress response pathways to detect and alleviate adverse conditions and preserve their cellular integrity. Stress responses are particularly important in stem cell

NIAID Data Ecosystem40

SIRT6 regulates redox homeostasis in human mesenchymal stem cells by the transactivation of NRF2

细胞氧化还原调控

表观遗传修饰

We investigated the effect of SIRT6-knockout on gene expression and H3K4me3 modification profile in human mesenchymal stem cells. Overall design: RNAs isolated from SIRT6+/+ and SIRT6-/- hMSCs at earl

NIAID Data Ecosystem40

SIRT6 regulates redox homeostasis in human mesenchymal stem cells by the transactivation of NRF2

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