CTCF is known to mediate long range chromatin intearction and 3D genome organization. In CD8+ T cells responding to actue infection, CTCF is redistributed to induce the the cytotoxic program while usi

NIAID Data Ecosystem50

Mitochondria-lysosome crosstalk dictates the progressive differentiation of Treg cells to limit inflammation-associated immunopathology [ATAC-seq2]

免疫细胞分化

染色质可及性分析

Chromatin profiling in WT and Opa1-deficient Treg cells. Overall design: CD45.2+CD45.1-CD4+Foxp3-YFP+ Treg cells were sorted from WT mixed BM chimera (n = 4) and Foxp3CreOpa1fl/fl mixed BM chimera (n

NIAID Data Ecosystem20

Effects of gene scilencing of USP2 on expression profiles of HL60 cells (PMA 3days and LPS 4hrs)

基因功能研究

免疫细胞分化

So far, we have found phorbol 12-myristate 13-acetate (PMA) induced ubiquitin specific peptidase (USP) 2b isoform in myeloid leukemia cell lines such as HL60, THP-1, and U937. HL60, THP-1, and U937 un

NIAID Data Ecosystem50

Additional file 7 of Single-cell transcriptomics highlights immunological dysregulations of monocytes in the pathobiology of COPD

单细胞转录组学

免疫细胞分化

Additional file 7: Dataset 5. Genes dynamically expressed during CD14+ classical monocyte-to-CD14+ intermediate monocyte differentiation, related to Fig. S3M and S3N, in which the top 250 genes based

Figshare2022-12-20 更新40

Expression of Human naïve B cell priming for plasma cell differentiation

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