Transcriptomic analysis of the pre-optic area and the mediobasal hypothalamus of female rats after perinatal exposure to ketoconazole or diethylstylbestrol

Because perinatal exposure to diethylstilbestrol (DES; strong estrogen) or ketoconazole (KTZ; steroidogenesis inhibitor) delayed vaginal opening and GnRH secretion in female rats, we studied the hypothalamic transcriptome to identify their target genes.鉴于围产期暴露于己烯雌酚（diethylstilbestrol, DES，强效雌激素）或酮康唑（ketoconazole, KTZ，类固醇生成抑制剂）可引发雌性大鼠阴道开口延迟及促性腺激素释放激素（gonadotropin-releasing hormone, GnRH）分泌延迟，本研究针对大鼠下丘脑转录组展开分析，以期鉴定这两种受试物质的靶基因。