Mechanisms of Sinoatrial Node Dysfunction in Heart Failure with Preserved Ejection Fraction

RNA sequencing from sinoatrial node tissue was performed to identify transcriptomic changes in Dahl salt-sensitive rats fed with normal salt diet (0.4% NaCl, control group) or high-salt diet (8% NaCl, HFpEF group) for 11 weeks. Transcriptomic profiling revealed numerous changes in multiple disease-associated genes in HFpEF, which is functionally related to the observed physiological impairments and structural remodeling.本研究对窦房结（sinoatrial node）组织开展RNA测序（RNA sequencing），以探究饲喂11周正常盐饮食（0.4% NaCl，对照组）或高盐饮食（8% NaCl，HFpEF组）的达尔盐敏感性大鼠的转录组变化。转录组分析结果显示，HFpEF组内存在多种疾病相关基因的显著表达改变，且此类改变与观测到的生理损伤及结构重构存在明确的功能关联。