Transcriptome analysis of Mycoplasma pneumoniae IV

Mycoplasma pneumoniae is a model organism for the minimal cell, so tit is believe to have the basic transcriptional machinery. To reconstruct its gene regulatory network, cells were treated with different drugs/perturbations or were challenged by gain or loss of function of candidate transcription factos and regulators, or a combination of both and RNAseq was performed. Perturbations allow to link the upstream signals and the putative regulators.