Fixed effects: age category (mother, pup), tissue (brain, muscle, oocyte pool, single oocyte [combined across all oocytes measured for a mouse]), mtDNA compartment (D-loop, non–D-loop), mutation type
Duplex sequencing of mtDNA from rhesus macaque somatic tissues (liver, skeletal muscle, and heart), and single oocytes was performed to study the effect of aging on mtDNA substitution frequencies. Mac
