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GIGYF2 regulates telomere length and cellular senescence by restricting telomerase access

Name: GIGYF2 regulates telomere length and cellular senescence by restricting telomerase access
Creator: School of Lifesciences, Sun Yat-sen University
Published: 2026-08-26T16:22:54+08:00

integrated proteome resources2026-08-29 收录

端粒长度调控

细胞衰老机制

数据链接：

https://www.iprox.cn/page/project.html?id=IPX0019241000 数据链接链接失效反馈

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资源简介：

GIGYF2 regulates telomere length and cellular senescence by restricting telomerase access

应用场景：

提供机构：

School of Lifesciences, Sun Yat-sen University

创建时间：

2026-08-26

细胞衰老机制

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Age-associated dysregulation of peroxisomal matrix protein importing impairs intestinal stem cell differentiation and gut functions

细胞衰老机制

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Age-associated dysregulation of peroxisomal matrix protein importing impairs intestinal stem cell differentiation and gut functions

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Human Keratinocytes That Express hTERT and Also Bypass a p16(INK4a)-Enforced Mechanism That Limits Life Span Become Immortal yet Retain Normal Growth and Differentiation Characteristics

角质形成细胞永生化

细胞衰老机制

Normal human cells exhibit a limited replicative life span in culture, eventually arresting growth by a process termed senescence. Progressive telomere shortening appears to trigger senescence in norm

PubMed Central40

Effect of overexpression of aging-associated transcription factors on epithelial cells.

细胞衰老机制

转录因子功能

RNA-seq profiling of whole, intact uteri at embryonic day 3.5 (E3.5) from young and aged virgin wild-type C57BL/6 miceâeach mated with vasectomized wild-type malesâidentified the transcription fac

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ATF3 drives senescence by reconstructing accessible chromatin profiles

细胞衰老机制

染色质可及性分析

We depicted the landscapes of both chromatin accessibility and gene expression to reveal gene regulatory networks in human umbilical vein endothelial cell (HUVEC) senescence and found that chromatin a

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GIGYF2 regulates telomere length and cellular senescence by restricting telomerase access

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