Transcriptome of Human Primary Corneal Endothelial Cells with SLC4A11 deficiency. Transcriptome of Human Primary Corneal Endothelial Cells with SLC4A11 deficiency

Mutations in the solute-linked carrier family 4 member 11 (SLC4A11) gene are associated with several corneal endothelial dystrophies, in all of which visually significant cornea edema may require corneal transplantation. To elucidate the pathogenesis of SLC4A11 associated corneal endothelial dystrophies, we analyzed the transcriptome of SLC4A11 knock-down primary human corneal endothelium (SLC4A11 KD pHCEnC) and scrambled RNA treated pHCEnC as controls. Overall design: 3 KD vs 3 CTRL