Mechanisms of suberoylanilide hydroxamic acid inhibition of mammary cell growth
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The mechanism of suberoylanilide hydroxamic acid in cell growth inhibition involved induction of pRb-2/p130 interaction and nuclear translocation with E2F-4, followed by significant repression in E2F-1 and PCNA nuclear levels, which led to inhibition in DNA synthesis in mammary epithelial cell lines.
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BMC创建时间：
2000-12-22
