Zebrafish tumors driven by overexpression of human IRF4
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2022-05-10
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Single cell RNA-seq analysis for normal lymphocytes and IRF4-driven zebrafish tumors
Single cell RNA-seq analysis was carried out for 1 normal sample from a control zebrafish line (lck-mCherry) and 5 non-tumor and 14 tumor samples from the IRF4 transgenic line (lck-IRF4). Tumor cells
NIAID Data Ecosystem50
Highly Aneuploid Zebrafish Malignant Peripheral Nerve Sheath Tumors have Genetic Alterations Similar to Human Cancers
Aneuploidy is a hallmark of human cancers, but most mouse cancer models lack the extensive aneuploidy seen in many human tumors. The zebrafish is becoming an increasingly popular model for studying ca
NIAID Data Ecosystem30
The human Ewing's Sarcoma oncoprotein EWS-FLI1 causes Ewing's-type tumors in zebrafish. Danio rerio
The fusion oncoprotein EWS-FLI1 arises from a t(11;22)(q24;q12) chromosomal translocation and causes Ewing's Sarcoma, a malignant bone tumor. The mechanism whereby EWS-FLI1 transforms cells is unknown
NIAID Data Ecosystem10
Tumor types developed by brca2 +/+; tp53 +/ m , brca2 +/ m ; tp53 +/ m , and brca2 m / m ; tp53 +/ m zebrafish.
Abbreviations: MPNST, malignant peripheral nerve sheath tumor; mo, months. IThe total numbers of each tumor type observed by histologic analysis are reported. Some zebrafish developed more than one tu
NIAID Data Ecosystem30
Expression data from murine irf4-/- and irf4+/+ mature B cells purified by magnetic cell separation
Gene expression profiling of murine irf4-/- and irf4+/+ splenic B cells identifies genes regulated by the transcription factor IRF4 in quiescent mature B cells. B cells from 12-week old irf4-/- and ir
NIAID Data Ecosystem30
