b4290dba-60d5-4af4-a857-5c0419dff5de - samples
收藏NIAID Data Ecosystem2026-03-10 收录
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资源简介：
Hotspot mutations in the spliceosome gene SF3B1 are reported in 20% of uveal melanomas. SF3B1 is involved in 3'-splice site (3'ss) recognition during RNA splicing; however, the molecular mechanisms of its mutation have remained unclear. Here we show, using RNA-Seq analyses of uveal melanoma, that the SF3B1 R625/K666 mutation results in deregulated splicing at a subset of junctions, mostly by the use of alternative 3'ss.EGA dataset EGAD00001004398
创建时间：
2018-11-09
