Enantioselective Palladium-Catalyzed Intramolecular α‑Arylative Desymmetrization of 1,3-Diketones

An efficient enantioselective protocol has been reported to build highly oxygenated and densely substituted bicyclo­[m.n.1] skeletons through intramolecular asymmetric α-arylative desymmetrization of 1,3-diketones. Employing Pd catalyst and FOXAP ligand, various bicyclo­[m.n.1] skeleton with different size can be accessed with high enantio- and diastereoselectivities. Utilizing the present method as a key step, formal asymmetric total synthesis of the (−)-parvifoline has been demonstrated.