UBL5 is essential for pre-mRNA splicing and sister chromatid cohesion in human cells
收藏官方服务：
资源简介：
UBL5 is essential for pre-mRNA splicing and sister chromatid cohesion in human cells
应用场景：
创建时间：
2014-08-05
相关数据集
Conformational dynamics of cohesin/Scc2 loading complex are regulated by Smc3 acetylation and ATP association. Conformational dynamics of cohesin/Scc2 loading complex are regulated by Smc3 acetylation and ATP association
The ring-shaped cohesin complex is the key player in sister chromatid cohesion, DNA repair, and gene transcription. The loading of cohesin to chromosomes requires the loader Scc2 and is regulated by A
NIAID Data Ecosystem50
Pseudouridine synthases modify human pre-mRNA co-transcriptionally and affect splicing
We performed pseudouridine profiling (Pseudo-seq) on 11 biological replicates of chromatin-associated RNA. We performed mRNA-seq of PUS1 knockout, PUS7 knockdown, RPUSD4 knockdown and wildtype HepG2 c
NIAID Data Ecosystem30
Releasing activity disengages cohesin’s Smc3/Scc1 interface in a process blocked by acetylation
Sister chromatid cohesion conferred by entrapment of sister DNAs within a tripartite ring formed between cohesin’s Scc1, Smc1, and Smc3 subunits is generated during S and eventually destroyed at anaph
Alliance of Genome Resources30
The Scc2NIPBL/Scc4MAU2 complex acts in sister chromatid cohesion and transcriptional regulation by maintaining nucleosome-free regions [microarray]. Saccharomyces cerevisiae
The Scc2/Scc4 complex binds to broad nucleosome-free regions in the promoters of highly expressed genes. The cohesin loader is recruited to these sites by the RSC chromatin remodeling complex Overall
NIAID Data Ecosystem40
Ultra-deep sequencing reveals pre-mRNA splicing as a sequence driven high-fidelity process. Ultra-deep sequencing reveals pre-mRNA splicing as a sequence driven high-fidelity process
Alternative splicing diversifies mRNA transcripts in human cells. While the spliceosome pairs exons with a high degree of accuracy, the rates of rare aberrant and non-canonical pre-mRNA splicing have
NIAID Data Ecosystem30
