Cryo-EM structure of human TRPV1 in complex with the analgesic drug SB-366791

Cryo-EM structure of human TRPV1 in complex with the analgesic drug SB-366791 Descriptor: (2E)-3-(4-chlorophenyl)-N-(3-methoxyphenyl)prop-2-enamide, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol, ... Authors: Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I. Deposit date: 2023-03-07 Release date: 2023-05-10 Last modified: 2024-10-23 Method: ELECTRON MICROSCOPY (2.29 Å) Cite: Human TRPV1 structure and inhibition by the analgesic SB-366791. Nat Commun, 14, 2023