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Plag1 overexpression cooperates with Evi1 overexpression and Gata1s mutation in leading to M7 leukemia

ChEBI2010-08-01 更新2026-07-21 收录

急性巨核细胞白血病

基因协同致癌作用

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-16679 数据链接链接失效反馈

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资源简介：

Plag1 overexpression cooperates with Evi1 overexpression and Gata1s mutation in leading to M7 leukemia

应用场景：

创建时间：

2010-08-01

急性巨核细胞白血病

基因表达调控

A high incidence of acute megakaryoblastic leukemia (AMKL) in Down syndrome patients implies that chromosome 21 genes have a pivotal role in AMKL development, but the functional contribution of indivi

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AMKL chimeric transcription factors are potent inducers of leukemia

急性巨核细胞白血病

嵌合转录因子致病机制

Acute megakaryoblastic leukemia in patients without Down syndrome is a rare malignancy with a poor prognosis. RNA sequencing of fourteen pediatric cases previously identified novel fusion transcripts

NIAID Data Ecosystem40

A stem cell model identifies two alternative cell fates in CBFA2T3::GLIS2-driven acute megakaryoblastic leukemia initiation

急性巨核细胞白血病

细胞疾病模型

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

NIAID Data Ecosystem20

RNA-SEQ Quantitative Analysis of WT and Mpl-del-overexpressing AMKL cell Transcriptomes. RNA-SEQ Quantitative Analysis of WT and Mpl-del-overexpressing AMKL cell Transcriptomes

急性巨核细胞白血病

RNA测序基因表达分析

In the previous studies, we reported that Mpl alternative splicing form Mpl-del overexpressed in acute megakaryoblasttic leukemia (AMKL) patients and mediated thrombopoietin signaling to promote AMKL

NIAID Data Ecosystem50

SON siRNA Treatment in MEG-01

急性巨核细胞白血病

SON基因功能研究

SON siRNA treatments were performed in an AMKL cell line, MEG-01. SON, a co-splicing factor and transcriptional regulator, is highly expressed in AMKL patients and cell lines. Moreover, SON is the sec

NIAID Data Ecosystem40

Plag1 overexpression cooperates with Evi1 overexpression and Gata1s mutation in leading to M7 leukemia

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