Influence of pregnancy and TAC on myocardial gene-expression.

Influence of pregnancy and transverse aorta constriction (TAC) on the expression of genes related to cardiac remodeling in apical myocardium of rats. Data were analyzed using two-way ANOVA and Holm-Sidak post hoc test. PKCα, protein kinase Cα, MHC, myosin heavy chain, ANP, atrial natriuretic peptide, BNP, brain natriuretic peptide, ANKRD1, ankyrin repeat domain-containing protein 1, TNFα, tumor necrosis factor α, TGF, transforming growth factor, VEGF, vascular endothelial growth factor, SOD1, superoxide dismutase 1, eNOS, endothelial nitric oxide synthase, iNOS, inducible nitric oxide synthase, COL1A1, collagen type I-a 1, COL3A1, collagen type III-a 1, FN1, fibronectin and TIMP1, tissue inhibitor of metallopeptidase 1. 0, no significant difference, ↑ increase p<0.05, ↑↑ increase p<0.001, ↓ decrease p<0.05, ↓↓ decrease p<0.001, na, non-applicable due to interaction.