The Mitochondrial Regulatory Network: Subcellular localization of Non-Coding RNA in the Heart

Non-coding RNAs (ncRNAs) mediate processes such as transcription, translation, and other diverse biological functions within the cell. A particular class of ncRNA, long ncRNA (lncRNA), can act as competitive endogenous RNAs, sequestering mRNAs and microRNAs; but, sequestration requires appropriate stoichiometric ratios to be efficient. The purpose of the current study is to characterize the subcellular localization of ncRNA within the mitochondrion, and to understand how import/export mechanisms may dictate changes in RNA diversity during disease progression.