To elucidate the function of Airn isoforms in the heart, we conducted RNA immunoprecipitation experiment followed by microarray (RIP-chip) in murine cardiomoycyte cell line HL-1. Using HL-1 cells, we
We have recently identified Fam64a as a fetal-specific gene, the primary function of which is promoting cardiomyocyte cell cycle. To gain deeper insight into the molecular function of Fam64a, we analy
(A) No difference in maximum averaged normalized shortening in day 30 WT-CMs and FCM-CMs. (B, C) Impaired maximum fractional shortening is evident in day 50 FCM-CMs compared with age-matched WT-CMs. (
The adenovirus carrying Mettl14 gene infects primary neonatal mouse cardiomyocytes, which is in contrast with the primary neonatal mouse cardiomyocytes infected with empty virus. The purpose is to exp
The use of single cell RNA sequencing (scRNA-seq) remains limited in cardiac pathology owing to technical difficulties associated with the isolation of single adult cardiomyocytes (CMs). Here, we inve
