Effect of catalase-transfected macrophages on inflammation and neurodegeneration in mice with PD model^a.

aBALB/c mice were i.c. injected with 6-OHDA. Forty eight hours later, the animals were i.v. injected with various macrophage-based formulations or PBS. Control group was i.c. injected with PBS, and then 48 hours later i.v. injected with PBS. bTotal number of neurons was calculated in ipsilateral hemisphere. cStatistical significance is shown by asterisk: p<0.05 (*), and p<0.005 (**) compared to mice with i.c. PBS injections followed by i.v. PBS injections (healthy controls); or p<0.05 (#),compared to mice with i.c. 6-OHDA injections followed by i.v. PBS injections (PD controls); was performed by a1+standard t-test. Errors are mean ± SEM, N = 7.