Multicomponent Synthesis of 1,3-Diketone-Linked <i>N</i>‑Substituted Pyrroles, Pyrrolo[1,2‑<i>a</i>]pyrazines, Pyrrolo[1,4]diazepines, and Pyrrolo[1,4]diazocines
收藏NIAID Data Ecosystem2026-03-10 收录
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A new methodology is developed for the efficient synthesis of 1,3-diketone-linked N-substituted pyrroles, pyrrolo[1,2-a]pyrazines, pyrrolo[1,4]diazepines, and pyrrolo[1,4]diazocines in good yields via a Yb(OTf)3-catalyzed, nitromethane-mediated reaction of primary amine/diamine, furfural, and 1,3-diketone. Possible mechanisms for these multicomponent reactions are also proposed.
创建时间：
2019-01-10
