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Site-specific CRISPR-based mitochondrial DNA manipulation is limited by gRNA import

NIAID Data Ecosystem2026-03-13 收录

线粒体基因编辑

CRISPR递送优化

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA851606 数据链接链接失效反馈

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资源简介：

Effect of Cas9-BE3 delivery to mitochondria.

应用场景：

创建时间：

2022-06-22

线粒体基因编辑

基因敲除小鼠

We design and apply a highly optimized library of double-stranded DNA deaminase (DddA)-derived cytosine base editors (DdCBEs) - MitoKO - to precisely ablate every mtDNA protein coding gene in the mous

NIAID Data Ecosystem70

Knockout of CMS-causative mitochondrial gene. Oryza sativa

水稻细胞质雄性不育

线粒体基因编辑

To determine whether a mitochondrial gene orf312 causes Tadukan-type cytoplasmic male sterility using mitochondrial-targeted TALEN

NIAID Data Ecosystem60

mitoTev‐TALE: a monomeric DNA editing enzyme to reduce mutant mitochondrial DNA levels

线粒体基因编辑

MERRF突变治疗

This work describes the development of a mitochondrial‐targeted DNA editing enzyme that can specifically cleave the MERRF m.8344A>G mtDNA mutation. The novel feature of this enzyme is that it is monom

HRA Figshare2026-03-16 更新30

Enhanced DdCBE with NES and mitoTALEN

线粒体基因编辑

基因治疗

Enhanced DdCBE for m.G12918A in mice with NES and mitoTALEN.

NIAID Data Ecosystem60

Predictability of DdCBEs mediated base editing in mitochondrial DNA

线粒体基因编辑

碱基编辑优化

DdCBE acts as the most commonly used editor for mtDNA, our understanding of the editing rules is very limited, especially for the aC targets, we need to optimize the editing strategies by adjusting th

NIAID Data Ecosystem40

Site-specific CRISPR-based mitochondrial DNA manipulation is limited by gRNA import

资源简介：

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