DMRdb

The Disease-centric Mendelian Randomization Database (DMRdb) is a database that offers insights into potential causal associations among diseases, genes, proteins, metabolites and CpG sites through the application of Mendelian randomization methods. Currently, the database mainly consists of three main components: 1) 6,640 disease-associated GWAS datasets that have been curated and structured manually; 2) Over 497 million outcomes derived from Mendelian randomization methods involving genes, proteins, metabolites, CpG sites and diseases; 3) Key findings extracted from 1223 pieces of literature that have been manually gathered and linked with diseases Mendelian randomization以疾病为中心的孟德尔随机化数据库（Disease-centric Mendelian Randomization Database, DMRdb）是一款通过运用孟德尔随机化（Mendelian randomization, MR）方法，系统解析疾病、基因、蛋白质、代谢物及CpG位点之间潜在因果关联的专业数据库。目前，该数据库主要包含三大核心组成部分：1. 经人工整理并完成结构化处理的6640份疾病关联全基因组关联研究（Genome-Wide Association Study, GWAS）数据集；2. 源自涉及基因、蛋白质、代谢物、CpG位点及疾病的孟德尔随机化分析的逾4.97亿条分析结果；3. 从1223篇经人工搜集的文献中提取的关键研究发现，并将这些发现与疾病及孟德尔随机化研究建立关联。

搜集汇总

背景与挑战

背景概述

DMRdb是一个疾病中心化的孟德尔随机化数据库，旨在通过孟德尔随机化方法系统评估疾病与基因、蛋白质、CpG位点、代谢物及其他疾病之间的潜在因果关系。该数据库主要包括6,640个手动整理的疾病相关GWAS数据集、超过4.97亿个涉及多类生物实体的孟德尔随机化分析结果，以及从1,223篇文献中提取并关联的关键发现。