IPI-549 bound to the PI3Kg catalytic subunit p110 gamma
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IPI-549 bound to the PI3Kg catalytic subunit p110 gamma Descriptor: 2-amino-N-[(1S)-1-{8-[(1-methyl-1H-pyrazol-4-yl)ethynyl]-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl}ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Authors: Burke, J.E, Rathinaswamy, M.K, Harris, N.J. Deposit date: 2020-08-26 Release date: 2021-03-17 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Disease related mutations in PI3K gamma disrupt regulatory C-terminal dynamics and reveal a path to selective inhibitors. Elife, 10, 2021
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2020-08-26
