A virus-infected cell triggers a signalling cascade resulting in the secretion of interferons (IFNs), which in turn induces the up-regulation of the IFN stimulated genes (ISGs) that play a role in ant
Using wild type mice and mice deficient for either IFNb1 or IFN-receptor, we analysed the effect of the constitutive IFN on genome-wide expression To look for the role of constitutive interferon, we c
In a cell line (NB4) derived from a patient with acute promyelocytic leukemia, all-trans-retinoic acid (ATRA) and interferon (IFN) induce the expression of a novel gene we call RIG-G (for retinoic aci
