Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, encoding for a chloride ion channel. Membrane expression of CFTR is negatively regul

NIAID Data Ecosystem70

Inhibition of H3K9 methyltransferase G9a ameliorates methylglyoxal-induced peritoneal fibrosis

纤维化治疗

组蛋白甲基化调控

Activity of H3K9 histone methyltransferase G9a is reportedly induced by transforming growth factor-β1 (TGF-β1) and plays an important role in the progression of cancer and fibrosis. In this study, we

NIAID Data Ecosystem40

Administration of glutaredoxin-1 attenuates liver fibrosis caused by aging and non-alcoholic steatohepatitis. Administration of glutaredoxin-1 attenuates liver fibrosis caused by aging and non-alcoholic steatohepatitis

纤维化治疗

非酒精性脂肪性肝炎

Glutaredoxin-1 (Glrx) controls redox signaling and has an anti-apoptotic function. We evaluated the role of Glrx on hepatic cell damage and fibrosis induced by a high-fat diet. We fed mice a high-fat

NIAID Data Ecosystem30

nNO measurements before and after two months and one year of ivacaftor therapy.

纤维化治疗

呼吸道疾病监测

nNO measurements before and after two months and one year of ivacaftor therapy.

NIAID Data Ecosystem50

YFP_quenching_assay_data

纤维化治疗

离子通道功能检测

Data for manuscript: Gain-of-function CFTR restores essential epithelial function with greater efficacy than wildtype or codon optimized CFTR when expressed in cystic fibrosis airway cells.

Figshare2023-08-09 更新40

Source Data-GLP-1R and GCGR dual-agonist recovers hepatic fibrosis

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