SERPINA3- a novel keratinocyte differentiation promotor mediates epidermal barrier repair response in psoriatic lesion. Homo sapiens

To excavate the genes regulated by SERPINA3, We profiled SERPINA3 silenced differentiated KC versus control using a RNA-seq approach. The genes down regulated in SERPINA3 silenced cells represent targets that are positively regulated by SERPINA3. Overall design: mRNA profiles of differentiated keratinocytes which are SERPINA3-silenced by 3 different siRNA and Scramble siRNA transfected differentiated keratinocytes were generated by deep sequencing.